The Growing Rate of Venous Thromboembolism Following Cancer Surgery

Venous Thromboembolism The Growing Rate of Venous Thromboembolism Following Cancer Surgery
The Growing Rate of Venous Thromboembolism Following Cancer Surgery

The Growing Rate of Venous Thromboembolism Following Cancer Surgery


Every year, millions of people around the world are diagnosed with cancer. Surgery is often a crucial element in the treatment plan for cancer patients, offering the potential for cure, improved survival rates, or enhanced quality of life. However, undergoing surgery also carries certain risks, one of which is the development of venous thromboembolism (VTE). This article explores the growing rate of VTE following cancer surgery and highlights the importance of preventive measures to mitigate this risk.

Venous Thromboembolism: Understanding the Condition

What is Venous Thromboembolism?

Venous thromboembolism is a medical term that refers to the formation of blood clots in veins, most commonly in the deep veins of the legs or the lungs. The condition encompasses two main components – deep vein thrombosis (DVT) and pulmonary embolism (PE).

The Link Between Cancer and Venous Thromboembolism

Studies have shown a strong association between cancer and an increased risk of VTE. Cancer patients have a four to seven times higher risk of developing VTE compared to the general population. The underlying mechanisms for this association are multifactorial, including factors such as procoagulant substances released by tumors, disruptions in the normal balance of blood coagulation factors, and inflammation.

The Growing Rate of VTE Following Cancer Surgery

An Alarming Trend

In recent years, there has been a noticeable increase in the rate of VTE occurrence following cancer surgery. This trend is particularly concerning given the potential harm that VTE poses to patients, including prolonged hospital stays, increased healthcare costs, and even death in severe cases. The precise reasons behind this surge in VTE rates warrant further investigation, but several factors may contribute to this phenomenon.

The Impact of Surgery on Coagulation Mechanisms

Cancer surgery disrupts the natural balance of coagulation mechanisms in the body, leading to an increased propensity for blood clot formation. The surgical trauma triggers a cascade of events, including platelet activation, release of pro-inflammatory cytokines, and endothelial damage, all of which can contribute to clot formation.

Immobility and Reduced Blood Flow

Patients undergoing cancer surgery often experience reduced mobility during the postoperative period, which can increase the risk of VTE. Immobility diminishes blood flow in the lower limbs, slowing down the circulation and facilitating clot formation. Additionally, surgical procedures that involve manipulation or removal of lymph nodes can disrupt the lymphatic system, further compromising blood flow and increasing the risk of VTE.

Impact of Chemotherapy and Hormone Therapy

Certain cancer treatments, such as chemotherapy and hormone therapy, may also contribute to the increased risk of VTE following surgery. Some chemotherapy drugs have been associated with a higher incidence of blood clot formation, while hormone therapy can disrupt the balance of coagulation factors in the body.

Preventing Venous Thromboembolism in Cancer Patients

The Role of Prophylactic Anticoagulation

Prophylactic anticoagulation, also known as thromboprophylaxis, plays a vital role in reducing the risk of VTE in cancer patients undergoing surgery. This involves the administration of blood-thinning medications, such as low molecular weight heparin or fondaparinux, to prevent blood clot formation. The duration and type of thromboprophylaxis depend on various factors, including the type of surgery, patient characteristics, and individual risk assessment.

Early Mobilization and Physical Therapy

Encouraging early mobilization and implementing physical therapy strategies can significantly reduce the risk of VTE in cancer surgery patients. Moving and exercising the legs helps promote blood flow, preventing stagnation and clotting. Healthcare professionals should prioritize postoperative ambulation and provide patients with specific exercises to perform while in the hospital and after discharge.

Educating Patients about VTE Risks

Patient education plays a crucial role in VTE prevention. Individuals scheduled for cancer surgery should receive comprehensive information about VTE risks, warning signs, and the importance of adhering to preventive measures. By increasing awareness and promoting proactive approaches, patients can actively participate in their own care, ultimately reducing the risk of postoperative VTE.


The growing rate of venous thromboembolism following cancer surgery is a concerning trend that demands attention. As the number of individuals diagnosed with cancer continues to rise, it is imperative for healthcare professionals to address this heightened risk of VTE. By implementing preventive measures, such as prophylactic anticoagulation, early mobilization, and patient education, the incidence of postoperative VTE can be significantly reduced, safeguarding the well-being of cancer patients during their treatment journey.


1. Can venous thromboembolism occur after any type of cancer surgery?

Yes, venous thromboembolism can occur after any type of cancer surgery. The risk may vary depending on factors such as the type and extent of surgery, patient characteristics, and underlying cancer type.

2. How long do patients need to continue thromboprophylaxis after cancer surgery?

The duration of thromboprophylaxis after cancer surgery depends on various factors and is determined by the treating healthcare professionals. In general, prophylactic anticoagulation is continued for a specific period post-surgery to mitigate the risk of venous thromboembolism.

3. Are there any signs or symptoms that patients should be aware of regarding venous thromboembolism?

Yes, patients should be vigilant for signs and symptoms of venous thromboembolism, which may include leg pain, swelling, warmth, and redness. In cases of pulmonary embolism, symptoms such as shortness of breath, chest pain, and coughing up blood may occur. It is crucial to consult a healthcare professional promptly if any concerning symptoms arise.[3]

Double Injury Blow: Ben Simmons of the Nets Sidelined Once Again

The Surprising Truth: Whether You Close the Toilet Lid Before Flushing Might Not Make a Difference